abstract：:Baicalein, wogonin, and oroxylin A are three major hydrophobic components in the extract of Radix scutellariae with wide spectrum of pharmacological applications. The purpose of this study was to enhance the solubility, dissolution rate and stability of baicalein, wogonin and oroxylin A by solid dispersion (SD) techni...

journal_title：International journal of pharmaceutics

authors： Yu H,Chang JS,Kim SY,Kim YG,Choi HK

更新日期：2017-08-07 00:00:00

abstract：:Andrographolide (AG) is a chemical entity from traditional Chinese herbs and its oral pills have been applied to the treatment of respiratory inflammation. Here we report pulmonary delivery of liposomal AG dry powder inhalers (LADPIs) for treatment of Staphylococcus aureus-induced pneumonia. AG liposomes were prepared...

journal_title：International journal of pharmaceutics

authors： Li M,Zhang T,Zhu L,Wang R,Jin Y

更新日期：2017-08-07 00:00:00

abstract：:Poly(ethylene glycol)-conjugated polyethylenimine (PEG-PEI) is a widely studied cationic polymer used to develop non-viral vectors for siRNA therapy of genetic disorders including cancer. Cell lines stably expressing luciferase reporter protein typically evaluate the transfection efficacy of siRNA/PEG-PEI complexes, h...

journal_title：International journal of pharmaceutics

authors： Rheiner S,Reichel D,Rychahou P,Izumi T,Yang HS,Bae Y

更新日期：2017-08-07 00:00:00

abstract：:New therapeutic strategies against inflammatory bowel disease (IBD) consider the usage of probiotics, prebiotics and synbiotics as beneficial for the intestinal microbial balance. Limitations of such an approach are addressed into difference in survival, persistence, colonization and variable effects among different p...

journal_title：International journal of pharmaceutics

authors： Ivanovska TP,Mladenovska K,Zhivikj Z,Pavlova MJ,Gjurovski I,Ristoski T,Petrushevska-Tozi L

更新日期：2017-07-15 00:00:00

abstract：:Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on t...

journal_title：International journal of pharmaceutics

authors： Pinďáková L,Kašpárková V,Kejlová K,Dvořáková M,Krsek D,Jírová D,Kašparová L

更新日期：2017-07-15 00:00:00

abstract：:The aim of this study was to elucidate the importance of potential limited solubility effects for the control of drug release from hydrophilic matrix tablets loaded with a freely water-soluble drug. It is often assumed that the considerable amounts of water penetrating into this type of advanced drug delivery systems ...

journal_title：International journal of pharmaceutics

authors： Siepmann F,Karrout Y,Gehrke M,Penz FK,Siepmann J

更新日期：2017-06-30 00:00:00

abstract：:The incorporation of micelle self-assembly in hydrogels has been used to produce self-healing materials, materials with tunable mechanical properties, and hydrophilic or hydrophobic drug delivery systems. However, little is known about the connection among formulation - structure - properties (particularly transport) ...

journal_title：International journal of pharmaceutics

authors： Munoz SZ,Zhadan R,Acosta E

更新日期：2017-06-30 00:00:00

abstract：:Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form s...

journal_title：International journal of pharmaceutics

authors： Callender SP,Mathews JA,Kobernyk K,Wettig SD

更新日期：2017-06-30 00:00:00

abstract：:The formation of extracellular aggregates built up by deposits of β-amyloid (Aβ) is a hallmark of Alzheimer's disease (AD). Curcumin has been reported to display anti-amyloidogenic activity, not only by inhibiting the formation of new Aβ aggregates, but also by disaggregating existing ones. However, the uptake of Curc...

journal_title：International journal of pharmaceutics

authors： Barbara R,Belletti D,Pederzoli F,Masoni M,Keller J,Ballestrazzi A,Vandelli MA,Tosi G,Grabrucker AM

更新日期：2017-06-30 00:00:00

abstract：:The purpose of this study is to improve the solubility, in vitro dissolution, and oral bioavailability in rats of tadalafil (TDF) by using SD technique with a weak acid and a copolymer. TDF-SD was prepared via solvent evaporation, coupled with the incorporation of an acidifier and solubilizer. Tartaric acid enhanced t...

journal_title：International journal of pharmaceutics

authors： Choi JS,Kwon SH,Lee SE,Jang WS,Byeon JC,Jeong HM,Park JS

更新日期：2017-06-30 00:00:00

abstract：:Co-delivery of chemotherapeutic agents improve anti-tumor efficacy and reduce cancer resistance. Here, we report development of layer-by-layer assembled gold nanoparticles (LbL-AuNP) containing anti-STAT3 siRNA and imatinib mesylate (IM) to treat melanoma. The combination treatment with STAT3 siRNA and IM in B16F10 me...

journal_title：International journal of pharmaceutics

authors： Labala S,Jose A,Chawla SR,Khan MS,Bhatnagar S,Kulkarni OP,Venuganti VVK

更新日期：2017-06-20 00:00:00

abstract：:HN-1, a 12-amino acid peptide, has been reported to possess strong capabilities for targeting and penetrating head and neck squamous cell carcinoma. Here, we designed a simple but effective nanoparticle system for the delivery of doxorubicin (DOX) targeting oral squamous cell carcinoma (OSCC) through the mediation of ...

journal_title：International journal of pharmaceutics

authors： Wang Y,Wan G,Li Z,Shi S,Chen B,Li C,Zhang L,Wang Y

更新日期：2017-06-15 00:00:00

abstract：:Developments in the field of molecular oncology have revealed that resistance to chemotherapeutics is acqured through several mechanisms including overexpression of common oncogenic proteins. Signal Transducer and Activator of Transcription 3 (STAT3) is one of these oncogenes that is overexpressed in many cancer types...

journal_title：International journal of pharmaceutics

authors： Kotmakçı M,Çetintaş VB,Kantarcı AG

更新日期：2017-06-15 00:00:00

abstract：:Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated cha...

journal_title：International journal of pharmaceutics

authors： Kääriäinen TO,Kemell M,Vehkamäki M,Kääriäinen ML,Correia A,Santos HA,Bimbo LM,Hirvonen J,Hoppu P,George SM,Cameron DC,Ritala M,Leskelä M

更新日期：2017-06-15 00:00:00

abstract：:Controlling microarchitecture in polymer scaffolds is a priority in material design for soft tissue applications. This paper reports for the first time the elaboration of alginate foam-based scaffolds for mesenchymal stem cell (MSC) delivery and a comparative study of various surfactants on the final device performanc...

journal_title：International journal of pharmaceutics

authors： Ceccaldi C,Bushkalova R,Cussac D,Duployer B,Tenailleau C,Bourin P,Parini A,Sallerin B,Girod Fullana S

更新日期：2017-05-30 00:00:00

abstract：:Drug delivery using suitable polymeric devices has gathered momentum in the recent years due to their remarkable properties. The versatility of polymeric materials makes them reliable candidates for site targeted drug release. Among them biodegradable sutures has received considerable attention because they offer grea...

journal_title：International journal of pharmaceutics

authors： Joseph B,George A,Gopi S,Kalarikkal N,Thomas S

更新日期：2017-05-30 00:00:00

abstract：:There is more research required to broaden the knowledge on the downstream processing of nanosuspensions into solid oral dosage forms, especially for coated nanosuspensions onto beads as carriers. This study focuses on bead layering as one approach to solidify nanosuspensions. The aim was to systematically investigate...

journal_title：International journal of pharmaceutics

authors： Parmentier J,Tan EH,Low A,Möschwitzer JP

更新日期：2017-05-30 00:00:00

abstract：:Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composi...

journal_title：International journal of pharmaceutics

authors： Haser A,Huang S,Listro T,White D,Zhang F

更新日期：2017-05-30 00:00:00

abstract：:The focus was on the development of medicated foam for incorporation of two incompatible active agents for psoriasis treatment; i.e., lipophilic cholecalciferol, and hydrophilic salicylic acid. Emphasis was given to formulation of a propellant-free foam, with sufficient foaming properties, physical and chemical stabil...

journal_title：International journal of pharmaceutics

authors： Mirtič J,Papathanasiou F,Temova Rakuša Ž,GosencaMatjaž M,Roškar R,Kristl J

更新日期：2017-05-30 00:00:00

abstract：:Achieving stable, efficient and non-toxic pulmonary gene delivery is most challenging requirement for successful gene therapy to lung. Composite nanoparticles (NPs) of the poly(lactic-co-glycolic acid) (PLGA) and cationic polymer polyethyleneimine (PEI) is an efficient alternative to viral and liposomal vectors for th...

journal_title：International journal of pharmaceutics

authors： Kolte A,Patil S,Lesimple P,Hanrahan JW,Misra A

更新日期：2017-05-30 00:00:00

abstract：:The unique properties of single-walled carbon nanotubes (SWNTs) enable them to play important roles in many fields. One of their functional roles is to transport cargo into cell. SWNTs are able to traverse amphipathic cell membranes due to their large surface area, flexible interactions with cargo, customizable dimens...

journal_title：International journal of pharmaceutics

authors： Li Z,de Barros ALB,Soares DCF,Moss SN,Alisaraie L

更新日期：2017-05-30 00:00:00

abstract：:Phthalocyanines (Pcs) are commonly used as Photosensors (PSs) in Photodynamic Therapy (PDT) applications due to their intense absorption in the far red-near IR spectral region with a high extinction coefficient and high ability for generating singlet oxygen. Pcs targetspecifically tumors, and do not show any considera...

journal_title：International journal of pharmaceutics

authors： Yurt F,Ince M,Colak SG,Ocakoglu K,Er O,Soylu HM,Gunduz C,Avci CB,Kurt CC

更新日期：2017-05-30 00:00:00

abstract：:The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery and production of individualized dosing and personalized treatments. In accordance with the changes observed in healthcare systems towards m...

journal_title：International journal of pharmaceutics

authors： Içten E,Purohit HS,Wallace C,Giridhar A,Taylor LS,Nagy ZK,Reklaitis GV

更新日期：2017-05-30 00:00:00

abstract：:Heart failure still represents the leading cause of death worldwide. Novel strategies using stem cells and growth factors have been investigated for effective cardiac tissue regeneration and heart function recovery. However, some major challenges limit their translation to the clinic. Recently, biomaterials have emerg...

journal_title：International journal of pharmaceutics

authors： Saludas L,Pascual-Gil S,Prósper F,Garbayo E,Blanco-Prieto M

更新日期：2017-05-25 00:00:00

abstract：:A multilayer mat for dispensing colistin sulfate through a body surface was prepared by electrospinning. The fabricated system comprised various polyvinyl alcohol fibrous layers prepared with or without the active ingredient. One of the electrospun layers contained water-soluble colistin sulfate and the other was prep...

journal_title：International journal of pharmaceutics

authors： Sebe I,Ostorházi E,Bodai Z,Eke Z,Szakács J,Kovács NK,Zelkó R

更新日期：2017-05-15 00:00:00

abstract：:Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear force application. Moreover, data obtaine...

journal_title：International journal of pharmaceutics

authors： Chang SY,Li JX,Sun CC

更新日期：2017-05-15 00:00:00

abstract：:Electrospun nanofibers are being utilized for a wide range of healthcare applications. A plethora of natural and synthetic polymers are exploited for their ability to be electrospun and replace the complex habitat provided by the extracellular matrix for the cells. The fabrication of nanofibers can be tuned to act as ...

journal_title：International journal of pharmaceutics

authors： Babitha S,Rachita L,Karthikeyan K,Shoba E,Janani I,Poornima B,Purna Sai K

更新日期：2017-05-15 00:00:00

abstract：:In this study, the active components of grape pomaces were first extracted by maceration in ethanol and propylene glycol, then in extra virgin olive oil. The main components of the hydrophilic extractive solutions were flavonoids, while monounsaturated fatty acids were the most abundant constituents of the extractive ...

journal_title：International journal of pharmaceutics

authors： Manconi M,Marongiu F,Manca ML,Caddeo C,Sarais G,Cencetti C,Pucci L,Longo V,Bacchetta G,Fadda AM

更新日期：2017-05-15 00:00:00

abstract：:Pharmaceutical thin films are versatile drug-delivery platforms i.e. allowing transdermal, oral, sublingual and buccal administration. However, dissolution testing of thin films is challenging since the commonly used dissolution tests for conventional dosage forms correspond rather poorly to the physiological conditio...

journal_title：International journal of pharmaceutics

authors： Laitinen R,Räty J,Korhonen K,Ketolainen J,Peiponen KE

更新日期：2017-05-15 00:00:00

abstract：:Corticosteroids have long been used to treat intraocular inflammation by intravitreal injection. We describe dexamethasone loaded poly-DL-lactide-co-glycolide (PLGA) microparticles that were fabricated by thermally induced phase separation (TIPS). The dexamethasone loaded microparticles were evaluated using a two-comp...

journal_title：International journal of pharmaceutics

authors： Awwad S,Day RM,Khaw PT,Brocchini S,Fadda HM

更新日期：2017-04-30 00:00:00

abstract：:The LR12 peptide has been reported to reduce the size of infarct and improve both cardiac function and survival in myocardial infarction in murine models, after daily repeated intraperitoneal injections. In order to protect peptide from degrading and to prolong its release, in situ implants based on biocompatible biod...

journal_title：International journal of pharmaceutics

authors： Parent M,Clarot I,Gibot S,Derive M,Maincent P,Leroy P,Boudier A

更新日期：2017-04-15 00:00:00

abstract：:Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis and activation, and although they display effectiveness in s...

journal_title：International journal of pharmaceutics

authors： Haggag YA,Matchett KB,Dakir el-H,Buchanan P,Osman MA,Elgizawy SA,El-Tanani M,Faheem AM,McCarron PA

更新日期：2017-04-15 00:00:00

abstract：:Multimodal imaging-guided multistage targeted synergistic combination therapy possesses many advantages including increased tumoricidal effect, reduced toxicity, and retarded drug resistance. Herein, we have elaborately developed a core-interlayer-shell structure Fe3O4@mSiO2@lipid-PEG-methotrexatenanoparticle(FMLM), i...

journal_title：International journal of pharmaceutics

authors： Liu G,Ma J,Li Y,Li Q,Tan C,Song H,Cai S,Chen D,Hou Z,Chen Q,Zhu X

更新日期：2017-04-15 00:00:00

abstract：:Lipid nanoparticles (LNs) are widely investigated for oral drug delivery, and for achieving significant advantages in colloidal stability, biocompatibility and scaled-up possibility. However, researchers face challenge of developing methods to improve the ability of LNs in overcoming multiple barriers (i.e., mucus and...

journal_title：International journal of pharmaceutics

authors： Wu L,Liu M,Shan W,Cui Y,Zhang Z,Huang Y

更新日期：2017-03-30 00:00:00

abstract：:Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid the acidic conversion of lovastatin to its hydroxyacid derivative. In a two-step process, sucrose beads were layered with a glass solution of ezetimibe, lovastatin and Soluplus®, top-coated with an ent...

journal_title：International journal of pharmaceutics

authors： Riekes MK,Dereymaker A,Berben P,Augustijns P,Stulzer HK,Van den Mooter G

更新日期：2017-03-30 00:00:00

abstract：:This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard Methocel CR and direc...

journal_title：International journal of pharmaceutics

authors： Van Snick B,Holman J,Cunningham C,Kumar A,Vercruysse J,De Beer T,Remon JP,Vervaet C

更新日期：2017-03-15 00:00:00

abstract：:In situ amorphization is a concept that allows to amorphize a given drug in its final dosage form right before administration. Hence, this approach can potentially be used to circumvent recrystallization issues that other amorphous formulation approaches are facing during storage. In this study, the feasibility of mic...

journal_title：International journal of pharmaceutics

authors： Doreth M,Hussein MA,Priemel PA,Grohganz H,Holm R,Lopez de Diego H,Rades T,Löbmann K

更新日期：2017-03-15 00:00:00

abstract：:A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40°C/75% RH. A number of solid state analytic...

journal_title：International journal of pharmaceutics

authors： Davis MT,Potter CB,Mohammadpour M,Albadarin AB,Walker GM

更新日期：2017-03-15 00:00:00

abstract：:This study sought to determine whether there is an evidence base for drug manipulation to obtain the required dose, a common feature of paediatric clinical practice. A systematic review of the data sources, PubMed, EMBASE, CINAHL, IPA and the Cochrane database of systematic reviews, was used. Studies that considered t...

journal_title：International journal of pharmaceutics

authors： Richey RH,Hughes C,Craig JV,Shah UU,Ford JL,Barker CE,Peak M,Nunn AJ,Turner MA

更新日期：2017-02-25 00:00:00

abstract：:The purpose of this study is designing non-viral gene delivery vectors for transfection of the primary human retinal pigment epithelial cells (RPE). In the design process of gene delivery vectors, considering physicochemical properties of vectors alone does not seem to be enough since they interact with constituents o...

journal_title：International journal of pharmaceutics

authors： Tasharrofi N,Kouhkan F,Soleimani M,Soheili ZS,Atyabi F,Akbari Javar H,Abedin Dorkoosh F

更新日期：2017-02-25 00:00:00